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Archives of Dermatology current issue

Panniculitis With Arthralgia in Patients With Melanoma Treated With Selective BRAF Inhibitors and Its Management [Observation]
Zimmer, L., Livingstone, E., Hillen, U., Domkes, S., Becker, A., Schadendorf, D. Mon, 16 Jan 2012 12:41:59 -0800
Background  Painful lobular panniculitis appears to be a novel cutaneous adverse effect of selective BRAF inhibitors. Observation  We report the clinical course and management in 2 women with metastatic melanomas harboring the BRAFV600E mutation, who developed panniculitis with arthralgia during therapy with selective oral BRAF inhibitors. Panniculitis with arthralgia was the acute presenting adverse effect in both patients. Painful, red, nodular lesions were located on the upper and lower extremities. Biopsy specimens of the nodules showed a mild, predominantly lobular neutrophilic panniculitis. Analgesic and anti-inflammatory treatment improved panniculitis and arthralgia in both cases. It was also necessary to reduce the BRAF inhibitor dose in 1 patient. Conclusions  During therapy with selective BRAF inhibitors, panniculitis with arthralgia represents a new adverse effect that can require dose reduction. In case of this adverse effect, treatment with nonsteroidal anti-inflammatory drugs, such as etoricoxib, should be initiated early to keep patients on treatment and to avoid drug discontinuation and tumor progression.

pubmed: 0001-5555

Herpes Zoster in Patients with Drug-induced Hypersensitivity Syndrome/DRESS.
Kano Y, Horie C, Inaoka M, Mizukawa Y, Shiohara T Herpes Zoster in Patients with Drug-induced Hypersensitivity Syndrome/DRESS. Acta Derm Venereol. 2012 Feb 6; Authors: Kano Y, Horie C, Inaoka M, Mizukawa Y, Shiohara T PMID: 22307980 [PubMed - as supplied by publisher]

Latest Issue of American Journal of Clinical Dermatology

Treatment of Cutaneous Warts: An Evidence-Based Review
DallOglio, FedericaDAmico, ValentinaNasca, Maria R.Micali, Giuseppe

Archives of Dermatological Research (Online First™)

The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation
Thu, 02 Feb 2012 18:09:59 -0000
Abstract  Anti-inflammatory therapeutic options for the topical treatment of skin diseases with inflammatory or allergic contribution are mostly limited to topical glucocorticoids and calcineurin inhibitors. Both compound classes induce adverse effects. Elevation of intracellular cyclic adenosine monophosphate (cAMP) by inhibition of phosphodiesterase 4 was shown to induce potent anti-inflammatory effects, but the safety profile of currently available compounds is not sufficient. A different approach to increase intracellular cAMP is the substitution of chemically stabilized cAMP analogues. Bucladesine is a stabilized cAMP analogue with an excellent safety profile which had been marketed as topical treatment of impaired wound healing. In the current study, a novel water free emulsion containing bucladesine was evaluated for anti-inflammatory effects. In the arachidonic acid induced ear oedema model in mice, single or multiple administration of an emulsion containing 1.5% was capable of significantly reducing the inflammatory oedema. The data indicate that bucladesine represents an interesting treatment option for skin diseases where an anti-inflammatory activity is indicated. Due to the established clinical safety, this agent may bridge the gap between potent agents such as glucocorticoids or calcineurin inhibitors and emollients without active compounds. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00403-012-1216-6Authors Chris Rundfeldt, Drug-Consult.Net, Toepfferspark 2a, 39108 Magdeburg, GermanyHartwig Steckel, Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Grasweg 9a, 24118 Kiel, GermanyTorben Sörensen, Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Grasweg 9a, 24118 Kiel, GermanyPiotr Wlaź, Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Akademicka 19, PL-20033 Lublin, Poland Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696

BMC Dermatology - Latest Articles

Measuring Melasma Patients' Quality of Life using Willingness to Pay and Time Trade-off Methods in Thai Population
Charussri LeeyaphanRungsima WanitphakdeedechaWoraphong ManuskiattiKanokvalai Kulthanan Mon, 19 Dec 2011 00:00:00 -0000
Background: Melasma is a common hyperpigmentation disorder that has a significant effect on an individual's quality of life. However, there is no preference-based measurement that reflects quality of life in patients with melasma. The objective of this study was to assess the impact of melasma on quality of life by using a health status measurement - the Dermatology Life Quality Index (DLQI) - and a preference-based measurement - Willingness to Pay (WTP) and Time Trade-Off (TTO). Methods: A cross-sectional descriptive study was conducted. Seventy-eight patients with melasma who attended the melasma clinic at Siriraj Hospital from February to March 2009 were recruited in this study. The Thai version of the DLQI, questionnaires about WTP, standard TTO, and daily TTO were used to assess patients' quality of life. Results: Seventy-seven (98.7%) patients were female with a mean age of 47.8 7.9 years. The mean health utility based on standard TTO was 0.96. The utility obtained by the daily TTO method was 0.92 and was significantly correlated with an economically inactive occupation (p<0.05). The mean monthly WTP for the most effective treatment was 1,157 baht (7.2% of monthly income), ranging from 100 to 5,000 baht (1 USD 35.1 baht). The WTP was significantly correlated with monthly personal income and the total DLQI score. Conclusion: The WTP method could be a useful tool with which to measure the quality of life of patients with melasma.

Dermatology : Last 20 articles

High Incidence of Internal Malignancy in Papuloerythroderma of Ofuji: A Case Series from Japan
Wed, 08 Feb 2012 00:00:00 +0100
Dermatology (DOI:10.1159/000335563)

pubmed: 1167-1122

Port-wine stains are more than skin-deep! Expanding the spectrum of extracutaneous manifestations of nevi flammei of the head and neck.
Eivazi B, Roessler M, Pfützner W, Teymoortash A, Werner JA, Happle R Port-wine stains are more than skin-deep! Expanding the spectrum of extracutaneous manifestations of nevi flammei of the head and neck. Eur J Dermatol. 2012 Jan 27; Authors: Eivazi B, Roessler M, Pfützner W, Teymoortash A, Werner JA, Happle R Abstract It is well known that port-wine stains of the upper part of the face may herald abnormalities of the brain or eye in the form of Sturge-Weber syndrome. This study focuses on other extracutaneous anomalies in patients with nevi flammei of the head and neck, giving rise to functional complications. Patients and methods. A retrospective study was performed on patients with port-wine stains involving the head and neck area. Records were reviewed for demographic parameters, extent of the lesion, clinical complications, diagnostic measures, previous treatments, ultimate therapeutic approach, and outcome. Results. Nine patients, mean age 50.4 years, with port-wine stains and clinical symptoms due to extracutaneous involvement, were admitted and treated from 2006 to 2009. Major clinical features included macrocheilia in three cases, gingival bleeding in two, dysphonia with globus sensation, painful parotideal swelling with recurrent otitis, painful lingual swelling, recurrent epistaxis, and nasal obstruction in one case each. Cases with lower lip hypertrophy were treated by conventional surgical approaches. Recurrent epistaxis and nasal obstruction due to affected inferior turbinate were treated by Nd:YAG laser therapy, and globus sensation and dysphonia by speech therapy. Patients with gingival affection and recurrent otitis were treated by local ear care. Conclusion. Port-wine stains in the head and neck may develop extracutaneous manifestations causing severe problems. A multimodal and interdisciplinary approach is mandatory for an appropriate treatment. PMID: 22285557 [PubMed - as supplied by publisher]

Exogenous Dermatology : Last 20 articles

Author Index Vol. 3, No. 4, 2004
Tue, 31 Jan 2006 00:00:00 +0100
Exog Dermatol 2004;3:201-202 (DOI:10.1159/000091311)

Expert Reviews: Expert Review of Dermatology: Table of Contents

Teledermatology: state-of-the-art and future perspectives
info@expert-reviews.com (Niccolò Nami et al) Fri, 27 Jan 2012 16:11:44 -0000
Expert Review of Dermatology , February 2012, Vol. 7, No. 1, Pages 1-3.

pubmed: 0022-202X

Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT.
Becker JC, Schrama D Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT. J Invest Dermatol. 2012 Jan;132(1):15-7 Authors: Becker JC, Schrama D Abstract The strict control of the T-cell receptor repertoire is essential for prevention of autoimmune diseases. The repertoire of T cells is primarily formed in the thymus through positive and negative selection. The risk of an incomplete removal of autoreactive T cells necessitates additional means to maintain peripheral tolerance. There is increasing evidence that the interferon (IFN)-γ-inducible lysosomal thiol reductase (GILT) allows peripheral tolerance to a melanocyte differentiation antigen by induction of specific regulatory T cells. PMID: 22158609 [PubMed - indexed for MEDLINE]

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