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Archives of Dermatology current issue
Panniculitis With Arthralgia in Patients With Melanoma Treated With Selective BRAF Inhibitors and Its Management [Observation]
Zimmer, L., Livingstone, E., Hillen, U., Domkes, S., Becker, A., Schadendorf, D. Mon, 16 Jan 2012 12:41:59 -0800
Background Painful lobular panniculitis appears to be a novel cutaneous adverse effect of selective BRAF inhibitors. Observation We report the clinical course and management in 2 women with metastatic melanomas harboring the BRAFV600E mutation, who developed panniculitis with arthralgia during therapy with selective oral BRAF inhibitors. Panniculitis with arthralgia was the acute presenting adverse effect in both patients. Painful, red, nodular lesions were located on the upper and lower extremities. Biopsy specimens of the nodules showed a mild, predominantly lobular neutrophilic panniculitis. Analgesic and anti-inflammatory treatment improved panniculitis and arthralgia in both cases. It was also necessary to reduce the BRAF inhibitor dose in 1 patient. Conclusions During therapy with selective BRAF inhibitors, panniculitis with arthralgia represents a new adverse effect that can require dose reduction. In case of this adverse effect, treatment with nonsteroidal anti-inflammatory drugs, such as etoricoxib, should be initiated early to keep patients on treatment and to avoid drug discontinuation and tumor progression.
pubmed: 0001-5555
Herpes Zoster in Patients with Drug-induced Hypersensitivity Syndrome/DRESS.
Kano Y, Horie C, Inaoka M, Mizukawa Y, Shiohara T Herpes Zoster in Patients with Drug-induced Hypersensitivity Syndrome/DRESS. Acta Derm Venereol. 2012 Feb 6; Authors: Kano Y, Horie C, Inaoka M, Mizukawa Y, Shiohara T PMID: 22307980 [PubMed - as supplied by publisher]
Latest Issue of American Journal of Clinical Dermatology
Treatment of Cutaneous Warts: An Evidence-Based Review
DallOglio, FedericaDAmico, ValentinaNasca, Maria R.Micali, Giuseppe
Archives of Dermatological Research (Online Firstâ„¢)
The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation
Thu, 02 Feb 2012 18:09:59 -0000
Abstract Anti-inflammatory therapeutic options for the topical treatment of skin diseases with inflammatory or allergic contribution are mostly limited to topical glucocorticoids and calcineurin inhibitors. Both compound classes induce adverse effects. Elevation of intracellular cyclic adenosine monophosphate (cAMP) by inhibition of phosphodiesterase 4 was shown to induce potent anti-inflammatory effects, but the safety profile of currently available compounds is not sufficient. A different approach to increase intracellular cAMP is the substitution of chemically stabilized cAMP analogues. Bucladesine is a stabilized cAMP analogue with an excellent safety profile which had been marketed as topical treatment of impaired wound healing. In the current study, a novel water free emulsion containing bucladesine was evaluated for anti-inflammatory effects. In the arachidonic acid induced ear oedema model in mice, single or multiple administration of an emulsion containing 1.5% was capable of significantly reducing the inflammatory oedema. The data indicate that bucladesine represents an interesting treatment option for skin diseases where an anti-inflammatory activity is indicated. Due to the established clinical safety, this agent may bridge the gap between potent agents such as glucocorticoids or calcineurin inhibitors and emollients without active compounds. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00403-012-1216-6Authors Chris Rundfeldt, Drug-Consult.Net, Toepfferspark 2a, 39108 Magdeburg, GermanyHartwig Steckel, Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Grasweg 9a, 24118 Kiel, GermanyTorben Sörensen, Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Grasweg 9a, 24118 Kiel, GermanyPiotr Wlaź, Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Akademicka 19, PL-20033 Lublin, Poland Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696
BMC Dermatology - Latest Articles
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Panniculitis With Arthralgia in Patients With Melanoma Treated With Selective BRAF Inhibitors and Its Management [Observation]
Zimmer, L., Livingstone, E., Hillen, U., Domkes, S., Becker, A., Schadendorf, D. Mon, 16 Jan 2012 12:41:59 -0800
Background Painful lobular panniculitis appears to be a novel cutaneous adverse effect of selective BRAF inhibitors. Observation We report the clinical course and management in 2 women with metastatic melanomas harboring the BRAFV600E mutation, who developed panniculitis with arthralgia during therapy with selective oral BRAF inhibitors. Panniculitis with arthralgia was the acute presenting adverse effect in both patients. Painful, red, nodular lesions were located on the upper and lower extremities. Biopsy specimens of the nodules showed a mild, predominantly lobular neutrophilic panniculitis. Analgesic and anti-inflammatory treatment improved panniculitis and arthralgia in both cases. It was also necessary to reduce the BRAF inhibitor dose in 1 patient. Conclusions During therapy with selective BRAF inhibitors, panniculitis with arthralgia represents a new adverse effect that can require dose reduction. In case of this adverse effect, treatment with nonsteroidal anti-inflammatory drugs, such as etoricoxib, should be initiated early to keep patients on treatment and to avoid drug discontinuation and tumor progression.
pubmed: 0001-5555
Herpes Zoster in Patients with Drug-induced Hypersensitivity Syndrome/DRESS.
Kano Y, Horie C, Inaoka M, Mizukawa Y, Shiohara T Herpes Zoster in Patients with Drug-induced Hypersensitivity Syndrome/DRESS. Acta Derm Venereol. 2012 Feb 6; Authors: Kano Y, Horie C, Inaoka M, Mizukawa Y, Shiohara T PMID: 22307980 [PubMed - as supplied by publisher]
Latest Issue of American Journal of Clinical Dermatology
Treatment of Cutaneous Warts: An Evidence-Based Review
DallOglio, FedericaDAmico, ValentinaNasca, Maria R.Micali, Giuseppe
Archives of Dermatological Research (Online Firstâ„¢)
The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation
Thu, 02 Feb 2012 18:09:59 -0000
Abstract Anti-inflammatory therapeutic options for the topical treatment of skin diseases with inflammatory or allergic contribution are mostly limited to topical glucocorticoids and calcineurin inhibitors. Both compound classes induce adverse effects. Elevation of intracellular cyclic adenosine monophosphate (cAMP) by inhibition of phosphodiesterase 4 was shown to induce potent anti-inflammatory effects, but the safety profile of currently available compounds is not sufficient. A different approach to increase intracellular cAMP is the substitution of chemically stabilized cAMP analogues. Bucladesine is a stabilized cAMP analogue with an excellent safety profile which had been marketed as topical treatment of impaired wound healing. In the current study, a novel water free emulsion containing bucladesine was evaluated for anti-inflammatory effects. In the arachidonic acid induced ear oedema model in mice, single or multiple administration of an emulsion containing 1.5% was capable of significantly reducing the inflammatory oedema. The data indicate that bucladesine represents an interesting treatment option for skin diseases where an anti-inflammatory activity is indicated. Due to the established clinical safety, this agent may bridge the gap between potent agents such as glucocorticoids or calcineurin inhibitors and emollients without active compounds. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00403-012-1216-6Authors Chris Rundfeldt, Drug-Consult.Net, Toepfferspark 2a, 39108 Magdeburg, GermanyHartwig Steckel, Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Grasweg 9a, 24118 Kiel, GermanyTorben Sörensen, Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Grasweg 9a, 24118 Kiel, GermanyPiotr Wlaź, Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Akademicka 19, PL-20033 Lublin, Poland Journal Archives of Dermatological ResearchOnline ISSN 1432-069XPrint ISSN 0340-3696
BMC Dermatology - Latest Articles
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Sites:
Science University (OHSU) Department of Dermatology: OHSU Dermatology Department (Oregon Health & Science University): patient information, faculty, residency program, research, department newsBaylor College of Medicine Department of Dermatology: Home page for Baylor College of Medicine, Department of Dermatology
Brigham and Womens Hospital Dermatology Department -BWH: A Boston, Massachusetts hospital, Brigham and Womens Hospital is a leader in womens health issues, patient care and medical research. BWH is consistently named at the top of the US News and World Reports hospital rankings.
Columbia University Presbyterian Hospital Department of Dermatology: Basic science research group, skin diseases and hair research and treatment centers, New York, New York.
Competence Center for Hair and Hair Diseases: Das Kompetenzzentrum für Haare und Haarerkrankungen ist an der Klinik für Dermatologie am Universitätsklinikum Charité der Humboldt-Universität zu Berlin. Wir beschäftigen uns mit schwierigen Haarerkrankungen und Problemfällen und erforschen die wissenschaftlichen Hintergründe von ausgewÃ...
Duke University Division of Dermatology: Division of Dermatology
Emory Department of Dermatology: Faculty and staff, training and education, clinical services and research center, Atlanta, Georgia.
Harvard Medical School Department of Dermatology: The Harvard Medical School Department of Dermatology is an integral part of the Harvard-affiliated hospitals. The department's mission is to provide leadership in the field of dermatology in four key areas. The department emphasizes dermatological care, adaptation to changes in the delivery of h...
Harvard Skin Disease Research Center- HSDRC: Investigators, immunology and pilot studies, useful links as well as a description of specialized research cores.
Indiana University Department of Dermatology: Overview, faculty, residency and fellowship programs, patient referrals, staff and dermatological resources, Indianapolis, Indiana.
Johns Hopkins Department of Dermatology: Information for physicians on patient care, education, research and for patients on specialty clinics, research and department news, Baltimore, Maryland.
Mayo Clinic Department of Dermatology: Department of Dermatology, Mayo Clinic in Rochester, Minn.
Penn State Dermatology: Penn State Dermatology provides the highest quality medical and surgical care to patients with skin disease and skin disorders.
Skin Care Centre: British Columbia's Centre for dermatologic science, a partnership of the Vancouver hospital sciences centre and the university of British Columbia division of dermatology, Vancouver, Canada.
Stanford University School of Medicine Department of Dermatology: Department information, patient services, education and research,Stanford, California.
Texas Tech University Department of Dermatology: Clinic information, publications and residency program, Lubbock, Texas.
The Ronald O. Perelman Department of Dermatology at New York University: Education, research, clinical studies, faculty, seminars and conferences as well as news, New York City, New York.
Tulane University Department of Dermatology: Academic overview, faculty, clinical services, residency program, research and case of the week, New Orleans, Louisiana.
University of Arkansas for Medical Sciences: Department of Dermatology
University of Iowa Department of Dermatology: The Dept of Dermatology, Univ of Iowa College of Medicine provides the highest quality medical & surgical care to patients with skin disease. Our site provides information for patients and medical professionals about skin disorders.
University of Virginia Health System Department of Dermatology Welcome: This is the homepage for the Department of Dermatology
University of Washington Dermatology Division: University of Washington School of Medicine, Department of Medicine, Division of Dermatology, Seattle, Washington, The University of Washington Division of Dermatology identifies, trains, and sustains excellent scholars and future leaders in dermatology.
Utrecht University Medical Center Department of Dermatology: Overview of laboratory, research, and clinic, the Netherlands.
Yale University Department of Dermatology: The Department of Dermatology at Yale, one of the oldest in the country, is deeply rooted in research and is now the largest provider of specialized dermatologic care in the region. We have widely recognized strength in many clinical areas.
This directory is based on the Open Directory and may have been modified